华中农业大学水产学院导师介绍：苏建国
苏建国 【教授】
| 姓名 | 苏建国 | 性别 | 男 |  |
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| 职称 | 教授 | 学位 | 博士 | |||||||||
| 电话 | 027-87282227 | 邮箱 | sujianguo@mail.hzau.edu.cn | |||||||||
| 工作单位 | 华中农业大学水产学院 | |||||||||||
| 研究方向 | 水生动物免疫学、免疫遗传学、表观遗传学 | |||||||||||
| 教育经历 | 1991.09 - 1995.07：学士，淡水渔业专业，上海水产大学渔业学院 1998.09 - 2001.12：硕士，动物遗传育种与繁殖专业，西北农林科技大学动物科技学院 2002.07 - 2005.07：博士，海洋生物学专业，中国科学院海洋研究所 |
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| 主要职历 | 1995.07 - 2000.11：助教，西北农林科技大学动物科技学院 2000.11 - 2005.12：讲师，西北农林科技大学动物科技学院 2003.06 - 2004.06：访问学者（国家留学基金委资助），澳大利亚联邦科学与工业联合组织（CSIRO） 2005.12 - 2009.12：副教授，西北农林科技大学动物科技学院 2006.04 - 2008.03：博士后，中国科学院水生生物研究所； 2009.12 - 2014.08：教授（四级岗），西北农林科技大学动物科技学院 2014.09 - 至今：教授（三级岗），华中农业大学水产学院 |
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| 科研成果 | A、科研项目
致力于养殖鱼类先天性抗病毒免疫系统的研究，提高养殖鱼类的免疫力，积极主动的应对疾病的发生。先后主持了西北农林科技大学科研专项、西北农林科技大学回国科研启动专项、教育部回国留学人员科研启动基金、农业部渔用药物创制重点实验室开放课题、淡水生态与生物技术国家重点实验室开放课题、中国博士后科学基金面上资助一等、西北农林科技大学“青年学术骨干支持计划”、西北农林科技大学校长基金、国家自然科学基金2项、教育部新世纪优秀人才支持计划、中央高校基本科研业务费专项、国家转基因重大专项子课题、“十二五”国家科技支撑计划子课题、华中农业大学新进高层次人才科研启动费等项目。
B、代表作 通讯作者) (*
1) Youliang Rao, Jianguo Su*, Chunrong Yang, Nana Yan, Xiaohui Chen, Xiaoli Feng. Dynamic localization and the associated translocation mechanism of HMGBs in response to GCRV challenge in CIK cells. Cellular & molecular immunology 2015; 12(3): 342-353. （SCI收录 2014 If=4.112）
2) Youliang Rao, Jianguo Su*. Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp. Journal of immunology research 2015; 2015: 670437.（SCI收录 2014 If=2.934）【Review Article】
3) Xueying Shang, Jianguo Su*, Quanyuan Wan, Juanjuan Su. CpA/CpG methylation of CiMDA5 possesses tight association with the resistance against GCRV and negatively regulates mRNA expression in grass carp, Ctenopharyngodon idella. Developmental & comparative immunology 2015; 48(1):86-94. （SCI收录 2014 If=2.815）.
4) Nana Yan, Jianguo Su*, Chunrong Yang, Youliang Rao, Xiaoli Feng, Quanyuan Wan, Chuzhao Lei. Grass carp SARM1 and its two splice variants negatively regulate IFN-I response and promote cell death upon GCRV infection at different subcellular locations. Developmental & comparative immunology 2015; 48(1):102-115. （SCI收录 2014 If=2.815）
5) Xiaohui Chen, Chunrong Yang, Jianguo Su*, Youliang Rao, Tianle Gu. LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells. Developmental & comparative immunology 2015; 49(1):138-148. （SCI收录 2014 If=2.815）
6) Juanjuan Su, Jianguo Su*, Xueying Shang, Quanyuan Wan, Xiaohui Chen, Youliang Rao. SNP detection of TLR8 gene, association study with susceptibility/resistance to GCRV and regulation on mRNA expression in grass carp, Ctenopharyngodon idella. Fish & shellfish immunology 2015; 43(1):1-12. （SCI收录 2014 If=2.674）
7) X. Fu, N. Li, Y. Lai, X. Luo, Y. Wang, C. Shi, Z. Huang, S. Wu and J. Su*. A novel fish cell line derived from the brain of Chinese perch Siniperca chuatsi: development and characterization. Journal of fish biology 2015; 86(1):32-45. （SCI收录 2014 If=1.658）
8) X.L. Cao, J.J. Chen, Y. Cao, G.X. Nie, Q.Y. Wan, L.F. Wang and J.G. Su*. Identification and expression analysis of the laboratory of genetics and physiology 2 gene in common carp Cyprinus carpio. Journal of fish biology 2015; 86(1):74-91. （SCI收录 2014 If=1.658）
9) Xiaoli Feng, Chunrong Yang, Yixuan Zhang, Limin Peng, Xiaohui Chen, Youliang Rao, Tianle Gu,Jianguo Su*. Identification, characterization and immunological response analysis of stimulator of interferon gene (STING) from grass carp Ctenopharyngodon idella.Developmental & comparative immunology 2014; 45(1):163-176. （SCI收录 If=2.815）
10) Xiaoli Feng, Jianguo Su*, Chunrong Yang, Nana Yan, Youliang Rao, Xiaohui Chen. Molecular characterizations of grass carp (Ctenopharyngodon idella) TBK1 gene and its roles in regulating IFN-I pathway.Developmental & comparative immunology 2014; 45(2):278-290. （SCI收录 If=2.815）
11) Xueying Shang, Jianguo Su*, Quanyuan Wan, Juanjuan Su, Xiaoli Feng. CpG methylationin the 5’-flanking region of LGP2 gene lacks association with resistance/susceptibility to GCRV but contributes to the differential expression between muscle and spleen tissues in grass carp, Ctenopharyngodon idella. Fish & shellfish immunology 2014; 40(1):154-163.（SCI收录 If=2.674）.
12) Youliang Rao, Jianguo Su*, Chunrong Yang, Limin Peng, Xiaoli Feng, Qingmei Li. Characterizations of two grass carp Ctenopharyngodon idella HMGB2 genes and potential roles in innate immunity. Developmental & comparative immunology 2013; 41(2):164-177. （SCI收录 If=3.705）
13) Quanyuan Wan, Jianguo Su*, Xiaohui Chen, Chunrong Yang. Gene-based polymorphisms, evolution analysis of IPS-1 gene and association study with the natural resistance to grass carp reovirus in grass carp Ctenopharyngodon idella.Developmental & comparative immunology 2013; 41(4):756-765. （SCI收录 If=3.705）
14) Quanyuan Wan, Jianguo Su*, Xiaohui Chen, Chunrong Yang, Lijun Chen, Nana Yan, Yixuan Zhang. Genomic sequence comparison, promoter activity, SNP detection of RIG-I gene and association with resistance/susceptibility to grass carp reovirus in grass carp (Ctenopharyngodon idella). Developmental & comparative immunology 2013; 39(4):333-342. （SCI收录 If=3.705）.
15) Xiaohui Chen, Qing Wang, Chunrong Yang, Youliang Rao, Qingmei Li, Quanyuan Wan, Limin Peng, Shuqin Wu*, Jianguo Su*. Identification, expression profiling of a grass carp TLR8 and its inhibition leading to the resistance to reovirus in CIK cells. Developmental & comparative immunology 2013; 41(1):82-93. （SCI收录 If=3.705）
16) Chunrong Yang, Limin Peng, Jianguo Su*. Two HMGB1 genes from grass carp Ctenopharyngodon idella mediate immune responses to viral/bacterial PAMPs and GCRV challenge. Developmental & comparative immunology 2013; 39(3):133-146. （SCI收录 If=3.705）.
17) Chunrong Yang, Qingmei Li, Jianguo Su*, Xiaohui Chen, Yaping Wang, Limin Peng. Identification and functional characterizations of a novel TRIF gene from grass carp (Ctenopharyngodon idella). Developmental & comparative immunology 2013; 41(2):222-229. （SCI收录 If=3.705）
18) Chunrong Yang, Lijun Chen, Jianguo Su*, Xiaoli Feng, Youliang Rao. Two novel homologs of high mobility group box 3 gene in grass carp (Ctenopharyngodon idella): Potential roles in innate immune responses. Fish & shellfish immunology 2013; 35(5):1501-1510. （SCI收录 If=3.034）
19) Lijun Chen, Qingmei Li, Jianguo Su*, Chunrong Yang, Yinqian Li, Youliang Rao. Trunk kidney of grass carp (Ctenopharyngodon idella) mediates immune responses against GCRV and viral/bacterial PAMPs in vivo and in vitro. Fish & shellfish immunology 2013; 34(3):909-919. （SCI收录 If=3.034）
20) Quanyuan Wan, Lan Wang, Jianguo Su*, Chunrong Yang, Limin Peng, Lijun Chen. Genetic structure, polymorphisms identification of LGP2 gene and their relationship with the resistance/susceptibility to GCRV in grass carp, Ctenopharyngodon idella. Gene 2013; 521(1):166-175. （SCI收录 If=2.082）
21) Quanyuan Wan, Jianguo Su*, Lan Wang, Limin Peng, Lijun Chen. Correlation between grass carp (Ctenopharyngodon idella) resistance to grass carp reovirus and the genetic insert-deletion polymorphisms in promoter and intron of RIG-I gene. Gene 2013; 526(2):320-327. （SCI收录 If=2.082）
22) Lijun Chen, Jianguo Su*, Chunrong Yang, Limin Peng, Quanyuan Wan, Lan Wang. Functional characterizations of RIG-I to GCRV and viral/bacterial PAMPs in grass carp Ctenopharyngodon idella. PLoS ONE, 2012; 7(7):e42182. （SCI收录If=3.730）
23) Limin Peng, Chunrong Yang, Jianguo Su*. Protective roles of grass carp Ctenopharyngodon idella Mx isoforms against grass carp reovirus. PLoS ONE, 2012; 7(12):e52142. （SCI收录If=3.730）
24) Jianguo Su（SCI收录 If=3.238） *, Jianfu Heng, Teng Huang, Limin Peng, Chunrong Yang, Qingmei Li. Identification, mRNA expression and genomic structure of TLR22 and its association with GCRV susceptibility/resistance in grass carp (Ctenopharyngodon idella). Developmental & comparative immunology 2012; 36(2): 450-462.
25) Quanyuan Wan, Jianguo Su*, Lan Wang, Lijun Chen, Xiaohui Chen. A 15 nucleotide deletion mutation in coding region of the RIG-I lowers grass carp (Ctenopharyngodon idella) resistance to grass carp reovirus. Fish & shellfish immunology, 2012; 33(2): 442-447. （SCI收录 If=2.964）
26) Chunrong Yang,Jianguo Su*, Qingmei Li, Rongfang Zhang, Youliang Rao. Identification and expression profiles of ADAR1 gene, responsible for RNA editing, in responses to dsRNA and GCRV challenge in grass carp (Ctenopharyngodon idella). Fish & shellfish immunology 2012; 33(4): 1042-1049. （SCI收录 If=2.964）
27) Lan Wang,Jianguo Su*, Chunrong Yang, Quanyuan Wan, Limin Peng. Genomic organization, promoter activity of grass carp MDA5 and the association of its polymorphisms with susceptibility/resistance to grass carp reovirus. Molecular immunology, 2012; 50(4): 236-243. （SCI收录 If=2.645）
28) C. Yang, J. Su*,R. Zhang, L. Peng and Q. Li. Identification and expression profiles of grass carp (Ctenopharyngodon idella) TLR7 in responses to double stranded RNA and virus infection. Journal of Fish Biology, 2012; 80(7):2605-2622. （SCI收录 If=1.834）
29) Jianfu Heng, Jianguo Su*, Teng Huang,Jie Dong, Lijun Chen. The polymorphism and haplotype of TLR3 gene in grass carp (Ctenopharyngodon idella) and their associations with susceptibility/resistance to grass carp reovirus. Fish & shellfish immunology, 2011;30(1):45-50. （SCI收录 If=3.322）
30) Chunrong Yang,Jianguo Su*,Teng Huang, Rongfang Zhang, Limin Peng. Identification of a retinoic acid-inducible gene I from grass carp (Ctenopharyngodon idella) and expression analysis in vivo and in vitro. Fish & shellfish immunology, 2011;30(3):936-943.（SCI收录 If=3.322）
31) Jianguo Su（SCI收录 If=3.322） *, Rongfang Zhang,Jie Dong, Chunrong Yang. Evaluation of internal control genes for qRT-PCR normalization in tissues and cell culture for antiviral studies of grass carp (Ctenopharyngodon idella). Fish & shellfish immunology 2011;30(3):830-835.
32) Jianguo Su（SCI收录 If=3.322） *, Teng Huang, Chunrong Yang, Rongfang Zhang. Molecular cloning, characterization and expression analysis of interferon-β promoter stimulator 1 (IPS-1) gene from grass carp Ctenopharyngodon idella. Fish & shellfish immunology, 2011;30(1):317-323.
33) Jianguo Su（SCI收录 If=2.929） , Limei Qiu*, Ling li, Lin Liu, Lingling Wang, Vinu S. Siva, Dahui Yu, Linsheng Song*. cDNA cloning and characterization of a new member of the tumor necrosis factor receptor family gene from scallop, Chlamys farreri. Molecular biology reports 2011;38(7): 4483-4490.
34) Lan Wang,Jianguo Su*, Limin Peng, Jianfu Heng, Lijun Chen. Genomic structure of grass carp Mx2 and the association of its polymorphisms with susceptibility/resistance to grass carp reovirus. Molecular immunology, 2011;49(1-2): 359-366.（SCI收录 If=2.897）
35) J. Su（SCI收录 If=1.685） *, J. Dong, T. Huang, R. Zhang, C. Yang and J. Heng. Myeloid differentiation factor 88 gene involves in antiviral immunity in grass carp Ctenopharyngodon idella. Journal of fish biology, 2011;78(3):973-979.
36) Teng Huang, Jianguo Su*, Jianfu Heng,Jie Dong, Rongfang Zhang, Huiming Zhu. Identification and expression profiling analysis of grass carp Ctenopharyngodon idella LGP2 cDNA. Fish & shellfish immunology, 2010;29(2):349-355.（SCI收录 If=3.044）
37) Jianguo Su（SCI收录If=3.044 ） *,Teng Huang,Jie Dong, Jianfu Heng, Rongfang Zhang, Limin Peng. Molecular cloning and immune responsive expression of MDA5 gene, a pivotal member of the RLR gene family from grass carp Ctenopharyngodon idella. Fish & shellfish immunology, 2010;28(4):712-718.
38) C. Yang and J. Su*. Molecular identification and expression analysis of Toll-like receptor3 incommon carp Cyprinus carpio. Journal of fish biology, 2010;76(8):1926-1939. （SCI收录 If=1.33）
39) Jianguo Su（SCI收录 If=2.892 ） *, Songhun Jang,Chunrong Yang,Yaping Wang, Zuoyan Zhu. Genomic organization and expression analysis of Toll-like receptor3 ingrass carp (Ctenopharyngodon idella). Fish & shellfish immunology, 2009;27(3):433-439.
40) Jianguo Su（SCI收录If=2.892） *,Chunrong Yang,Feng Xiong, Yaping Wang, Zuoyan Zhu. Toll-like receptor 4 signaling pathway can be triggered by grass carp reovirusand Aeromonas hydrophila infection in rare minnow Gobiocypris rarus. Fish & shellfish immunology, 2009;27(1):33-39.
41) Jianguo Su（SCI收录 If=2.892） , Chunrong Yang,Zuoyan Zhu,Yaping Wang*, Songhun Jang, Lanjie Liao. Enhanced resistance to grass carp reovirus infection in Mx-transgenic rare minnow (Gobiocypris rarus). Fish & shellfish immunology, 2009;26(6):828-835.
42) Jianguo Su（SCI收录If=2.892） , Zuoyan Zhu*,Yaping Wang*, Songhun Jang. Isolation and characterization of Argonaute 2: a key gene of the RNA interference pathway in the rare minnow, Gobiocypris rarus. Fish & shellfish immunology, 2009;26(1):164-170.
43) Jianguo Su,（SCI收录If=1.925） Zuoyan Zhu*,Yaping Wang, Jun Zou,Na Wang, Songhun Jang. Grass carp reovirus activates RNAi pathway in rare minnow, Gobiocypris rarus. Aquaculture, 2009;289(1-2):1-5.
44) Jianguo Su（SCI收录 If=3.161） , Zuoyan Zhu*, Yaping Wang. Molecular cloning, characterization and expression analysis of the PKZ gene in rare minnow Gobiocypris rarus. Fish & shellfish immunology, 2008;25(1-2):106-113.
45) Jianguo Su（SCI收录 If=3.161） , Dang TH Oanh, Russell E Lyons,Lisa Leeton, Marielle CW van Hulten, Siok-Hwee Tan,Linsheng Song, Rajendran Kooloth Valappil, Peter J Walker*.A key gene of the RNA interference pathway in the black tiger shrimp, Penaeus monodon: Identification and functional characterisation of Dicer-1. Fish & shellfish immunology, 2008;24(2):223-233.
46) Jianguo Su, （SCI收录If=2.793） Zuoyan Zhu*,Yaping Wang, Jun Zou, Wei Hu.Toll-like receptor 3 regulates Mx expression in rare minnow Gobiocypris rarus after viral infection. Immunogenetics, 2008;60(3-4):195-205.
47) Jianguo Su（SCI收录 If=2.544） , Zuoyan Zhu*,Feng Xiong, Yaping Wang. Hybrid cytomegalovirus-U6 promoter-based plasmid vectors improve efficiency of RNA interference in zebrafish. Marine biotechnology, 2008;10(5):511-517.
48) Jianguo Su,（SCI收录If=2.544） Zuoyan Zhu*,Yaping Wang,Feng Xiong, Jun Zou. The cytomegalovirus promoter-driven short hairpin RNA constructs mediate effective RNA interference in zebrafish in vivo. Marine biotechnology, 2008;10(3):262-269.
49) Jianguo Su（SCI收录 If=3.16 ） ,Duojiao Ni, Linsheng Song*,Jianmin Zhao, Limei Qiu. Molecular cloning and characterization of a short type peptidoglycan recognition protein (CfPGRP-S1) cDNA from Zhikong scallop Chlamys farreri. Fish & shellfish immunology, 2007;23(3):646-656.
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| 备注 | 2007年西北农林科技大学青年学术骨干支持计划入选者；2008年教育部新世纪优秀人才支持计划入选者；2014年湖北省楚天学者特聘教授入选者；2015年淡水水产健康养殖湖北省协同创新中心-淡水水产病害防控创新平台-病理与免疫及生物制剂研制PI。 | |||||||||||
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