张青叶

姓名：张青叶

性别：女

职称：副教授

学位：博士

电话：027-87280877

邮箱：zqy@mail.hzau.edu.cn

工作单位：

华中农业大学信息学院

研究方向：

蛋白质结构分析及药物发现研究

教育经历：

2003/09-2008/06，华中师范大学，化学学院，硕博连读

1999/09-2003/07，安庆师范学院，化学系，本科

主要职历：

2014/07- 至今 华中农业大学，信息学院，副教授

2011/01-2014/06，华中农业大学，理学院，副教授

2010/10-2010/12，华中农业大学，理学院，讲师

2008/07-2010/09，华中农业大学，生命科学技术学院，博士后

科研成果：

近年主持的科研项目：

1、博士后一等资助，项目名称： 苏云金芽胞杆菌YBT-1520的代谢网络调控研究，起止年限：2008.08-2010.09

2、博士后特别资助，项目名称：基于Glmu靶酶结构的新型抑制剂先导化合物的合理设计与筛选，起止年限：2009.10-2011.06

3、国家自然科学基金，项目名称：GlmU靶酶活性中心与其配体相互作用的机理及其抑制剂先导结构的研究，起止年限：2010.01-2012.12

4、华中农业大学培育专项，项目名称：基于靶酶结构的新型抑制剂结构的优化设计与合成，起止年限：2011.05-2012.12

近年发表的文章：

1、Jingnan Jin, Xiaojuan Qi, Dandan Yao, Bangqiang Mao, Jianhong Li, Qing Y. Zhang* and Changshui Chen*. Rational Design and Screening Study of Novel Lead Compound Based on Acetohydroxyacid Synthase Structure. Chem Biol Drug Des, 86, 316-324, 2014. (IF: 2.469)

2、Xia-Li Yue Hu Li Shuang-Shuang Liu Qing Y. Zhang* Jing-Jing Yao Fei-Yan Wang. N-Fluorinated phenyl-N’-pyrimidyl urea derivatives: Synthesis, biological evaluation and 3D-QSAR study. Chinese Chemical Letters. 25, 1069-1072, 2014. (IF: 1.178)

3、Jing Wang1, Qing Y. Zhang1, Zongqing Huang, Ziduo Liu∗ Directed evolution of a family 26 glycoside hydrolase: Endo- b -1,4-mannanase from Pantoea agglomerans A021. J of Biotechnology 167, 350-356, 2013. (IF: 3.183, the first two authors contributed equally)

4、Jun Min, Da Lin, Qing Y. Zhang*, Jibing Zhang, Ziniu Yu. Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU. Eur. J. Med. Chem. 53, 150-158, 2012. (IF: 3.499)

5、Jingnan Jin, Hongju Ma, Xiufang Cao, Shengzhen Xu, Jianhong Li, Qing Y. Zhang*, Changshui Chen. The discovery of the novel lead compound of N-nitroureas target on acetohydroxyacid synthase. Pestic. Biochem. Phys. 104, 218-223, 2012. (IF: 2.111)

6、Qing Y. Zhang, Chan Yu, Jun Min, Yan Wang, Jin He, Ziniu Yu*. Rational Questing for Potential Novel Inhibitors of FabK from Streptococcus pneumoniae by Combining FMO Calculation, CoMFA 3D-QSAR Modeling and Virtual Screening.J. Mol. Model. 17, 1483-1492, 2011. (IF: 1.871）

7、Jun Min, Xiaoli Zhang, Lei Wang, Xia Zou, Qing Y. Zhang*, Jin He*. Mutational analysis of the interaction between a potential inhibitor luteolin and enoyl-ACP reductase (FabI) from Salmonella enterica. J. Mol. Catal b-Enzym. 68, 174-180, 2011. (IF: 2.330)

8、Qing Y. Zhang, Ding Li, Yangliang Ren, Jie Zhang, Jian Wan, Pei Wei, Zhigang Chen, Deli Liu, Ziniu Yu. Structure-based Rational Screening of Novel Hit Compounds with Structural Diversity for Cytochrome P450 Sterol 14a-demethylase from Penicillium digitatum. J. Chem. Inf. Model. 50, 317-325, 2010. (IF: 3.822)

9、Jingjing Yao1, Qing Y. Zhang1, Jun Min, Jin He*, Ziniu Yu*. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Bioorg. Med. Chem. Lett. 20, 56-59, 2010. (IF: 2.661，the first two authors contributed equally)